LAW FOR BUSINESS Assignment Essay Example | Topics and Well Written Essays - 1250 words - 2

LAW FOR BUSINESS Assignment - Essay Example In general, compensation for economic loss resulting from damage to property can be recovered. As such, it is difficult to clearly distinguish between pure and consequential economic loss. This was demonstrated in Spartum Steel and Alloys Ltd v Martin &Co, wherein, the defendant had by inadvertence caused damage to an electronic cable in the plaintiff’s factory. The outcome of this act was a reduction in profits, and a general delay in the functioning of the factory. The court while awarding damages for the pure economic loss caused, rejected the claim for general damages (Speaight, 2009, p. 23). The compensation was with regard to the economic loss that was the direct outcome of the damage to property. The floodgates argument has several features. One of these contends that allowing recovery for pure economic loss in some instances would result in a plethora of lawsuits, which would effectively diminish the functioning of the courts. Furthermore, the imposition of widespread liability would unfairly and disproportionately burden a defendant. In addition, the defendant would be hard pressed to assess his potential liability on causing damage to the effects of a primary victim (von Bar, Drobnig, & Alpat, 2004, p. 124). The number of secondary loss sufferers becomes indeterminate and depends on all those who have an economic interest in the primary victim’s property. ... 19). On several occasions, the floodgates argument has been employed, in order to restrict liability. Thus, the House of Lords admitted this argument in Majrowski v Guys and St. Thomas’s NHS Trust. In this case, it was held that an employer could be deemed to be vicariously liable for an employee’s breach of the Protection from Harassment Act 1997. Moreover, in Conn v City Council of the City of Sunderland, the Appellate Court ruled that classifying an act as harassment would depend upon the place and context in which it had taken place. Consequently, it dismissed the plaintiff’s claim of injury as the language employed by the supervisor had been what was commonplace in that industry. In the case of Weller v Foot and Mouth Disease Research Institute, the inadvertent release of a virus from the defendant’s institute, resulted in a near epidemic of foot and mouth disease among the cattle of that area. As a result, the farmers in that area had to slaughter th eir cattle, and auctions could not be conducted. The auctioneers made a claim for damages. In its ruling, the court held that the auctioneers had merely undergone an indirect financial loss, and were therefore not eligible to claim damages (Harpwood, 2008, p. 87). Thus, the floodgates argument has been successfully contained by the judiciary. This is evident from the ruling in the above cited cases. Question Two: Extent of Accountant’s Liability to Non – Clients An accountant’s liability, with regard to clients and non-clients was determined through the judgement of the courts in the following cases. A negligent misrepresentation, despite being honest, can result in a claim for damages. This holds good, even if there had been no contract

Fulbright Research Proposal Essay Example for Free

Fulbright Research Proposal Essay Claudia Ukonu, Netherlands, Interdisciplinary Studies The Effects of User Generated Content on Cross Channel Communication Strategies Summary As a recipient of the 2013-2014 Fulbright Grant I plan to enroll in the Masters in Methodology and Statistics for Behavioural, Biomedical and Social Sciences at Utrecht University in the Netherlands. While completing this degree I will also conduct a research study where I will seek to answer two questions 1) How Dutch companies use cross channel communication strategies to market new products and 2) How user generated content (i. . Facebook, Twitter, Instagram, Pinterest, etc. ) effects the implementation of those cross channel communication strategies. The study will use surveys, interviews and statistical methods to examine purchasing behavior and the relevant results will be analyzed with the establishment of an internship at a Dutch market research firm. My goal in completing this study is to apply the knowledge gained from my Masters courses to the relevant topic of consumer purchasing behavior, which will build a solid foundation for entering a PhD program in Statistics. Introduction Here in the United States Pinterest, YouTube, Twitter, Facebook, Tumblr, and Instagram have become the way of projecting a glamorized image of oneself online. The idea of being modest and not bragging about one’s newly purchased Lamborghini or vacation to Tahiti is long gone. Consumers are now becoming the trendsetters as they now dictate the trends that companies tailor their products around. Examining how user generated content fulfills the Esteem and Love/Belonging parts of Maslow’s Hierarchy of Needs can be used as a model for predicting consumer habits. With the creation of social media networks, traditional ways of marketing seem to have little to no relevance. In order for companies to be effective when introducing new products and maintaining existing ones, it is vital that they are up to date with current trends in marketing new products through multiple communication channels. While each of these channels may have different demographics (i. e. the age difference between Facebook users and people who read newspapers) the goal of cross channel communication strategy is to ensure that the product being marketed conveys the same message on all channels. This can be a daunting task given the number of communication channels available to companies. Location In 2011, ComScore named the Netherlands as the number one country with the highest LinkedIn and Twitter penetration. This provides the perfect backdrop to see how Dutch companies are not only using cross channel communication strategies but, more specifically, how they are incorporating social media into those strategies. During the grant period I will be under the supervision of Dr.  Irene Klugkist, Associate Professor of Methodology and Statistics in the Graduate School of Social and Behavioural Sciences at Utrecht University. Methodology Upon arriving in Utrecht I will begin my MSc in Methodology and Statistics for Behavioural, Biomedical and Social Sciences at Utrecht University. I will enroll in the following courses for the fall semester: Advanced Survey Design and Missing Data Analysis, Multivariate Statistics, Foundations of Statistics, and Computational Inference with R. During the first two months in Utrecht I will spend my time focusing on becoming familiar with the foundations of statistics. In order to obtain accurate results when trying to determine the objectives of the study, it is vital that a selection of study participants is made. The participants will remain the same throughout the course of the study. This will be accomplished with the help of a study participant letter that will outline who I am, my purpose of study, what information I will collect from participants and how that information will be used in the study. I propose that no less than 100 participants be selected for the study. Having more participants will allow for a greater range of differentiation as well as data collection. The first two months of the grant period is also when I will spend time locating the participants of the study. I plan to include participants who are current students and working professionals. The demographics of my study will focus on men and women who are between the ages of 18-35. I am open to the possibility of changing these demographics given that after some time of living in Utrecht, I discover a niche market, to which this study’s objectives would be more relevant. The second objective‘How user generated content (i. e.  Facebook, Twitter, Instagram, Pinterest etc. ) affects the implementation of cross channel communication strategies will be partially addressed in months 3-7 of the grant period. It is during this time that I will track the social behavior of the study participants. Relevant factors to the collection of this data will include: the time the post was made on the social network, the content of the post and responses to the original post. Surveys will also be given to participants asking about their desire to purchase items marketed on various communication channels. The first objective of the study will be applied in the form of an internship at a Dutch marketing firm where I will first observe the current cross communication strategies. After doing this, I will analyze the data collected in the first portion of the grant period. This analysis will help to determine whether 1) Consumer purchasing behavior can be predicted on the basis of user generated content and 2) If this behavior can be predicted, how can companies utilize this to their advantage. Dr.  Klugkist has expressed willingness to help me secure an internship for months 8-9 at a Dutch market research firm. During the internship I will examine the past and existing cross communication strategies of the company while looking at what factors went into the planning of this strategy. Part of the MSc program requires students to participate in a traineeship in their desired field (Behavioural, Biomedical or Social Sciences) in their final year of study. Dr. Klugkist sent my research proposal to Dr.  Van Hattum, a former Utrecht student who now works at a market research firm and he expressed interest in having me as a trainee during my final year at Utrecht University. Goal Throughout the study I hope to uncover cross communication opportunities that utilize social media and then use those opportunities as a foundation upon which I will develop new and existing product entry strategies. I will be able to apply this research and the resulting Masters degree to the completion of a PhD in Statistics.

Relationships In The Novel The Road

Relationships In The Novel The Road The Road by Cormac McCarthy is a fantasy which revolves around two characters, a father and a son. I am doing a character sketch on the man and the boy because I find them to have the most fascinating personalities. The book narrates a father and son journeying through what happens to be North America, to the warmer South America. They have no money, few clothes, and barely any food. They stop at every village and town too scavenge and search for food. This is represented when the man and the boy find an underground bunker in a village full of useful essentials. The author lays emphasis on the theme of survival, and the significance it has on the man and the boy. The father appears to be very smart with a good eye for danger. He is quite skillful with weapons this is portrayed when he fond an underground bunker, he had found bullets but for the wrong gun so he whittled fake bullets from a treebranch with his knife. He also understands how to use his surrounding accurately, this is shown when in the end of the novel the man has an encounter with some villagers and has to think fast. On the other hand, the boy seems somewhat illiterate about the outside world, he knows nothing about firearms and all he knows is what his father has taught him during the years. The boy is also very scared in the novel, when it comes to looking in the towns or cities for food. The novel shows the progression of father and sons relationship, you see it growing bigger and stronger. Knowing that the boy does not have a mother anymore the father tries as much as he can to compensate for that. For example the boy and the man find a locked door in the ground while out s earching in a village. The man is tired and was resting between each shovelful while trying to uncover the bunker. However a few weeks before they had found a door and inside were they found other people whose limbs worn torn off and a boy on a splint on top of a fire being roasted for food. The man, no matter how scared the boy was, opens the door and finds a safe house full of food, water, gasoline, and other useful things. This tells that whatever the boy says to his father he will not listen however important it is, but only to save their lives. Therefore we learn that he is a father who would do anything for their son, and that he is the stereotypical Dad. He is the protector, provider and preserver for his son. This is shown in many instances as the father put the boy in the bunk and smoothed his filthy hair on the pillow and covered him with blankets. During the course of the novel, you see the boy become an independent man. He has got more confidence and has much more awareness around him. He understands that what his father does is only for him, and he loves no-one more. His mother died some time before this New World came to life. The man has raised the boy all by himself. He tries to teach him everything there is to know. The boy has also missed out on many luxuries that the man finds in one instance. The father finds Coca Cola and he asks the boy to try it and the boy responds by saying What is it, Papa? He also teaches him his alphabet. You get to know this from reading the end of the book, where he asks him Can you write the alphabet?, and he the boy responds by saying I can write it. We also learn that the boy wants to help other people that have lost their way, need help, or food. For they meet a man who cannot see well. The boy then insists on spending the night with this man and giving him some food and some warmth for the night. This shows us that even though the boy is very scared he is also very caring and wants to help other people that come across their path. He doesnt mind giving up his own food or his own clothing he just wants to help people around him. The boy shows a lot of compassion and a sense of social responsibility; you can see that the boy has a warm character and a soft heart towards everyone. However the father is not like a mirror image of the son, he trusts no-one. He believes in one for ones self, and has experienced a lot of suffering. The father has also lost a lot of loved ones and is emotional scarred and he thinks that the only way to stop this is to cut out all other people in his life. At the end of the novel, the father dies because he loses too much blood from an arrow wound, when the man was trying to protect the boy when they were at a town, trying to get some food. However, some village folk started to shoot at them thinking that they are carnivores. The boy waits by his side for 3 days, waiting for someone to come and help him. At the end a man, his wife and children were walking pass and decide to take him with them. He sees that the boy has supplies that they need and offer to help. The boy doesnt leave without covering his dad with a blanket, and saying his last goodbyes. The novel is written in sparse but moving prose. Cormac McCarthy uses simplifed formatting for his novel. There are no speech marks throughout the story. To provide us the adrelinin rush and to create tension throughout the novel McCarthy uses short sentences. The style that he writes in highlights the bond between the father and the son. I think that the boy is a symbol for hope, courage, and commitment. I felt a sense of pride in the ability of men to look after children even in difficult times. The novel inspires me to understand what families go through when they fight for survival.

No-calorie Powder May Substitute For Foods Fat :: essays research papers

No-Calorie Powder May Substitute for Food's Fat George E. Inglett of the U.S. Department of Agriculture's Biopolymer Research Unit in Peoria III invented a no-calorie fat substitute called Z-Trim. It is a mix of crushed fibers made from the hulls of grains. It can replace the fat and some of the carbohydrates in foods such as chocolates, brownies, cheese, and ground beef. He spent three years trying to perfect Z-Trim to be smooth because he made it out of tough hulls of corn, oats, and rice. He first crushed the hulls with a solution of hydrogen peroxide. He washed the peroxide off in centrifuge. After this step it was still too large, so he put the pieces back through the first step of the hydrogen peroxide and the centrifuge. That made it smooth. Now, it is a fine, white cellulose powder that can be made into a gel by adding water. Inglett also developed Oatrim. This is made up of a digestible fiber from oat flour that provides four calories per gram. Z-Trim compared to another fat substitute, olestra, is different. Olestra can cause gastrointestinal distress and take vitamins and carotenoids out of the body. The new substitute does not have those affects. Inglett says that you should eat more of the kind of fibers that make up Z-Trim to reduce the chances of getting intestinal disorders. But there are some people who argue with Inglett's theory on his new substitute. "I wouldn't expect Z-Trim to have the same kinds of problems as olestra," says Margo Wootan, a senior scientist at the Center for Science in the Public Interest in Washington, D.C. "Fiber is already found in our diet, while olestra is a synthetic chemical. There is also concern for the "microbial stability" of foods containing Z-Trim. "Whenever you remove the lipid material and replace it with water," says Thomas H.

Medicines and drugs Essay

A drug or medicine is a chemical that alters incoming sensory sensations, mood or emotions, or physiological state. Painkillers, hallucinogens and alcohols are examples of drugs and medicines that alter incoming sensory sensations. Prozac and alcohol alter mood or emotions Steroids, cigarettes and heart medicines alter physiological state, including consciousness, activity level or coordination. Drugs such as antiseptics, antibiotics and antivirals are infection fighters; hormones and vitamins affect body chemistry or metabolism; stimulants, depressants, analgesics and anesthetics affect the central nervous system and the brain. It is also important to understand that the human body has great natural healing processes; some drugs just increase the rate of natural healing. Also, there could be a placebo effect, it is when a pharmacologically inert substance that make seems to help because the person taking the substance was told that it would work. Placebo effect is examined by giving sugar pills to one group of tests patients, and real drugs to another group (when they are not aware of which they receive). B.1.2: Outline the stages involved in research, development and testing of new pharmaceutical products. This takes a very long time and costs a fortune, and is often controlled by the government. Before drugs are tested on humans, they must be testing on various animals (start with small animals and then go to bigger ones). The range of effective doses, the doses in which side-effects arise and the lethal doses have to be determined. There are 3 phases then; clinical trial; clinical evaluation (more in depth analysis); human studies with more evaluation, Very few drugs make it to the market, and the development would have cost a lot. Sometimes, things can still go wrong, like Thalidomide. It was given to pregnant women to treat morning sickness, but it cause deformities in babies! Now it is still used, but to treat skin sores. B.1.3. Describe the different methods of administering drugs * Oral: Very convenient. However, it might not be reliable as the rate of absorption depends on drug concentration, stomach content and pH value. As most is absorbed in the small intestines, so the drug must survive the gastric acid. Therefore it often lays in time release capsules. * Rectal: Good when drug cannot be taken orally due to vomiting or because the drug is pH sensitive. * Inhalation: Rapid, as there are loads of blood vessels in the lungs, and therefore a drug would have a reliable effect. Good for general anaesthesia, and asthma medicine. * Parental o Just below the skin; slower than for intravenous. Used often for dental injections o Into muscles; for large doses, or when immediate response is not needed (vaccines etc). o Intravenous; almost instantaneous, but cannot be undone when injected! Fatty lipids may bind some kinds of drugs, so the drugs won’t leave the body so fast The half life of a drug is the time for half the dose in the body to be eliminated. B.1.4. Discuss the terms lethal dosage (LD50), tolerance and side effects. LD50 is the lethal dose for 50% of the population; and it varies a lot from drug to drug. When one is tolerant, then one has to take a larger dose in order to feel the wanted effects. Some people after often use of a drug becomes dependant on it; physically (they must have it to be able to function physically) or psychologically (they must have it to feel right). Tolerance doesn’t necessarily mean that one gets used to the harmful effects. Sometimes it is hard to know the difference between main effect and side effect. A drug has many effects, and some patients benefit from a few of those effects; then those are the main effects, and all the other are side effects. Someone else, with another disease may benefit from other effects, and then those become the main effects. There are always harmful effects too. The risk : benefit ratio should also be considered. B.2.1. State and explain how excess acidity in the stomach can be reduced by the use of different bases. Bases, most often metal oxides, hydroxides, carbonates or hydrogen carbonates are used as antacids. These react with acid in the stomach to adjust the pH value. The purpose of gastric acid is to kill off bacteria, and help in digestion. However, over-eating or stress stimulates more production of acid, causing discomfort. The active ingredients tend to be; this react only with HCl: Magnesium Oxide: Magnesium Hydroxide: Aluminium Hydroxide: Calcium Carbonate: Sodium Hydrogen Carbonate: Magnesium Trisilicate: Some of the products; Carbon dioxide is a gas. So a foaming agent has to be added to prohibit excessive belching. Also alginates are used, to prevent acid reflux. If too much antacid is used, the stomach becomes too basic, and that hurts too; then more antacid might be wrongly taken. This leads to alkalosis. B.3.2. Describe the use of derivatives of salicylic acid as mild analgesics and compare the advantages and disadvantages of using aspirin and paracetamol (acetaminophen) Salicylic acid is used as an anti-pyretic (fever reducer) and mild analgesic (painkiller), but it is a strong acid and hurts the stomach and mouth; so variations of salicylic acid was used. One is Acetyl Salicylic Acid (ASA) or Aspirin, which has the benefits of salicylic acid and does not irritate so much due to the acetyl group. When ASA reacts with water, it becomes salicylic acid, and the by-product of ethanoic acid. GOOD: It is good for killing minor pain, reducing fever, acting as an anti-inflammatory agent and prevents abnormal blood clot. BAD: Upsets stomach and bleeding; allergy; accidental poisoning in infants and Reye’s syndrome. Acetaminophen is also an anti-pyretic and analgesic. However it does not upset the stomach and is safe. However, overdose can still occur and lead to liver and brain damage. And it is not anti-inflammatory. Ibuprofen is like aspirin and cause fewer stomach problems. It is anti-inflammatory and is very safe. B.3.3. Compare the structures of morphine, codeine and the semi-synthetic opiate heroin. These are strong analgesics and are often called opiates, narcotics or narcotic analgesics. The major pain relieving substance originates from the opium poppy plant is sleep inducing and pain relieving. All three share the same skeleton. Remember the group C2H3O2 is called an acetyl group. B.3.4. Discuss the advantages and disadvantages of using morphine and its derivatives as strong analgesics. These affects: The Central Nervous System, the Eye and the Gastrointestinal tract (the digestive system) They are used as: Strong analgesics (severe pain from injury and chronic diseases); treatment of diarrhoea, relieve coughing. However they are very addictive and are rather replaced with something else. They also produce mood changes, drowsiness and mental clouding. Tolerance can arise by adaptation of the liver and neurons in the brain. Some people can’t function without the drug, feeling restlessness, sweating, fever, chills, vomiting, aches etc due to abstinence of the drug. There is often severe psychological dependence too (one might feel extremely depressed).’à ¯Ã‚ ¿Ã‚ ½ Short term effects: Sedation, stupor, pain relief, euphoria, reduced tension, worry, couching reflex. One might die of overdose. Long term effects: Loss of appetite, sterility, withdrawal illness, crime, diversion of energy. B.4.1. Describe the effects of depressants Tranquilizers, sedatives and hypnotics, which calm and relax; they slow down heart rate and breathing. Tranquilizers include alcohol, Valium and Librium and are weaker than the others. These relieve anxiety and tension. Sedatives: Barbituates that soothe distress without producing much sleep in small doses. Hypnotics: Like chloral hydrate. These induce sleep. Too much can lead to coma or teach. B.4.2. Discuss the social and physiological effects of the use and abuse of ethanol. Social effects: Major costs from alcohol are from sickness and death, as in hospital treatments and lost efficiency. Property crimes and crimes against people; drinking while driving. Physiological effects: Harmful to relationships, and may physically or emotionally harm others. One may lose control and develop dependence and tolerance. It increases blood pressure when drinking and nausea, sweating and anxiety as withdrawal of use. Short-term effects: CNS depressant reduces tension. It triggers Euphoria, Talkativeness, Dilation of blood vessels, Violent behaviours, Inertia, Coma, Death. Long term effects: Cirrhosis, liver cancer, coronary heart disease, high blood pressure, strokes, gastritis, low birth mass etc. Alcohol can be used for antiseptics such as mouthwashes. B.4.3. Describe and explain the techniques used for the detection of ethanol in the breath of in the blood or urine. Ethanol passes from the stomach into the blood and therefore it passes into the lungs and ethanol vapour is formed. The breathalyser test might involve a redox equation with potassium dichromate: as oxidizing agent. Color change: Red-Orange to Green The gas liquid chromatography works as follows: Small samples of gases and volatile liquids such ethanol are separated. These are pushed through a column using an unimportant gas, such as Nitrogen gas and different gases take different time to come to the detector, where concentration of gases are measured. Intoxilyzer, Infra-red spectroscopy: Infra-red energy make molecules vibrate. Different types of bonds absorb and vibrate at different infer-red frequencies. By measuring how much energy is not absorbed by the molecules, one can find the number of certain bonds in the molecules. B.4.4. Describe the synergistic effects of ethanol with other drugs. Alcohol is easily absorbed in the stomach, so drugs that can be dissolved in alcohol will be absorbed much quicker, and the dosage will seem higher as in normal conditions the liver removes a part of the drug. So performance of the drug is enhanced and may lead to devastating effects such as death, especially if alcohol is combined with barbituates. Alcohol with aspirin increases the risk of stomach bleeding. B.4.5 . List other commonly used depressants and describe their structures. Valium (diazepam) is a tranquilizer, Mogadon (Nitrazepam) is a hypnotic drug (used to control seizures and infantile spasms), Prozac (hydrochloride) is an anti-depressant drug used to treat mental depression. Diazepam and Nitrazepam have similar carbon skeletons meanwhile Prozac is different. B.5.1. List the physiological effects of stimulants. Stimulants are chemicals that stimulate the brain and the central nervous system. It is the opposite of a depressant. These increase alertness. Examples are amphetamine, nicotine and caffeine. B.5.2. Compare amphetamines and adrenaline They both derive from the phenylethylamine structure, and therefore look similar. Furthermore, amphetamines mimic the effects of adrenaline (they are sympathomimetic drugs), as they constrict arteries and thus increases sweat production. They increase heart rate, blood pressure, respiration and insomnia. Medical uses: Treat mild depression, narcolepsy and asthma. They use up the body’s reserve energy and can lead to a collapse. B.5.3 Discuss the short- and long-term effects of nicotine consumption. Tobacco is a source of nicotine which is a mild stimulant with a short lived effect. The response is followed by depression and thereby makes one pushed to use it more often. Short-term: Increase in heart-rate and blood pressure. It constricts blood vessels and therefore strains the heart. Nicotine also reduces urine output. Long term effects of nicotine: It stresses hard and may lead to heart diseases and blood clot; May lead to increase of fatty acids in the blood. Smoking leads to more carbon monoxide in the blood making the blood less able to carry blood. It also increases the gastric acid production and may lead to ulcer. Smoking causes: Cancer in lungs and mouth; heart and blood vessel disease; breathing difficulties and chronic bronchitis; air pollution; fires; bad teeth; insomnia. B.5.4. Describe the effects of caffeine and compare its structure with that of nicotine. Caffeine stimulates the respiratory system (more energy is available from respiration), so heart and brain gets more energy. So one becomes more alert, motivated and well-being. In small amounts in is rather harmless, but too much causes insomnia. One gets more urine as well. Caffeine leads to some tolerance but no physical addiction. It can be given to babies to help their breathing. It also constricts blood vessels and therefore helps against migraines. Both caffeine and nicotine contain a tertiary amine group. Caffeine has more of those though. B.6.1. Describe the historical development of penicillins. In 1928, Fleming accidentally saw that some types of fungi killed off a certain bacterium and started to try to isolate the fungi, but it was too hard to purify it. In 1940, Floray and Chain continued with penicillin testing and development, and in 1943 it was available clinically. The first penicillin was Penicillin G. However it was deactivated by stomach acid so it had to be injected. Acid resistance penicillins such as penicillin V was developed by modifying the side chains of the basic penicillin structure. Some bacteria could deactivate penicillin G by synthesising an enzyme, therefore one had to make other synthetic penicillins. 6-APA penicillin is inert, but an extra amino group H2N would activate it. B.6.2. Compare broad spectrum and narrow spectrum antibiotics A broad spectrum antibiotics is effective against a wide variety of bacteria. Examples are tetracyclines. Narrow ones are effective only against certain types of bacteria; most penicillins are narrow spectrum antibiotics. One often has to determine the bacterium before getting antibiotics, because a broad-spectrum one can kill beneficial bacteria and give discomfort. B.6.3. Explain how penicillins work and discuss the effects of modifying the side chain. The cell walls of some bacteria are composed of polysaccharides, and these layers are supported by cross-links. However, penicillins interfere with the formation of these links and therefore weaken the structure. The bacteria can easily burst. Animals cells don’t have these cell walls and are therefore not affected. It is important to modify the side chain to work against bacteria have evolved and are able to break down certain types of penicillin. Side chains are also added to make the penicillin work (as for the 6-APA) and to survive the gastric acid (Penicillin G) B.6.4. Discuss and explain the effect over prescription of penicillins has, and the use of penicillins in animal feedstock Repeated use may lead to allergic reactions. They can also wipe out harmless and beneficial bacteria in the food canal, and harmful bacteria might eventually replace these. Bacteria can become resistant against certain antibiotics and then pass on their immunity. In feedstock: They are used to kill dangerous pathogens which may otherwise endanger humans and animals. They are also used to increase productivity. However, this increases the chances that bacteria might become resistant. B.7.1. State how viruses differ from bacteria Bacteria are relatively large single cell microorganism with DNA strands. Viruses are noncellular and are much smaller and are not living. They can only reproduce within a host cell. B.7.2. Describe the different ways in which antiviral drugs work * Block the transfer of genetic information * Control by inoculation, vaccines. * Block the enzyme activity in a host cell, so that the virus can’t use it to replicate. B.7.3. Discuss the difficulties associated with solving the AIDS problem HIV molecules bind to proteins on T-type of white blood cells and hinder them from fighting infections by inactivating them. HIV virus is good at mutating and together with their similarities with human cells, it is very heard to treat with antiviral drugs and vaccines. B.8.1. Describe the importance of geometrical isomerism in drug action. Stereoisomers are isomers with the same molecular formula and the same structural formula, but different arrangement of atoms in space. Geoemetric isomers have different physical properties such as polarity, boiling point, and solubility etc. They may also undergo different t chemical reactions although their functional groups are identical. For example cisplatin is en effective anti-cancer drug (as it may enter the nucleus of a cancerous cell), but the trans-isomers is inactive in such purposes. B.8.2. Discuss the importance of chirality in drug action. Optical isomers differ from geometric isomers in two ways: * Optical isomers are chiral (asymmetric) * Optical isomers are non-superimposable mirror images of each other One optical isomer rotates the plane polarized light one direction, meanwhile its other isomer rotates it the other way. An equi-molar mixture of two enantiomers means a 50-50 ration and will not totate the plane of polarised light at all; this is a racemic mixture. Penicillin V is active, but its enantiomer is inactive. One enantiomer of Thalidomide could be used to treat morning sickness in pregnant women and was marketed as a racemix mixture, but its other enantiomer gave foetal deformities. B.8.3. Describe the use of chiral auxiliaries to form the desired enantiomer. It is very heard to separate racemic mixtures into separate enantiomers, as they have identical chemical properties in relation to non-chiral reagents. Instead, scientists use stereospecific synthesis to produce only one kind of enantiomer. Chiral auxiliaries are used to convert non-chiral molecules into a desired enantiomer by attching itself chemically to the non-chiral molecule so that only one type of enantiomer can be formed. After the procedure the auxiliary can be recycled. This is used when synthesising Taxol which isa drug effective against breast cancer. B.8.4. Explain the use of combinatorial chemistry to synthesise new drugs. This is when one creates lots of molecules and test them quickly for biological properties; one starts with a set of basic chemicals which are then combined in all possible combinations, and this allows a fast production of many different molecules, increasing the chance of finding better drugs. A library is a collection of compounds that are screened to determine their usefulness as a drug, using parallel synthesis (identical processes with many different molecules at the same time). B.9.1. Compare local and general anaesthetics in terms of their modes of action Local anaesthetics block the pain in specific areas when they are injected under the skin or used as a crà ¯Ã‚ ¿Ã‚ ½me. Examples are cocaine, procaine, benzococaine, lidocaine etc. These block local nerve transmissions and decrease blood supply to that area. Procaine and lidocaine do not affect the brain, meanwhile cocaine does. General anaesthetics affect the brain and produce unconsciousness. But it is easy to reverse the unconsciousness. Examples are nitrous oxide, diethyl ether, chloroform, cyclopropane and halothane. B.9.2. Compare the structures and effects of cocaine, procaine and lidocaine. All three have the benzene ring and the tertiary amine. Cocaine also stimulates the central nervous system. It constricts blood vessels which leads to high blood pressure, and can’t be safely used. Although it doesn’t produce withdrawal symptoms and tolerance, it produces a strong psychological addiction. An overdose suppresses heart and respiration. Cocaine has a very short half life as it is metabolized by the liver fast, and is poorly absorbed when taken orally. Procaine gives prolonged relief from pain which is good for surgery and dental procedures. It is non-toxic and non-irritant. Lidocaine is used topically to produce numbness. It is more potent that procaine, but may cause swelling and itching. B.9.3. Discuss the advantages and disadvantages of nitrous oxide, ethoxyethane, trichloromethane, cyclopropane and halothane. Nitrous oxide is not very potent, and makes one feel good Trichloromethane is nonflammabe, but leads to liver damages. Narrow safety margin Ethoxyethane alleviates the pain in surgery well, but it is very flammable and nonstable. Cyclopropane is a very potent anaesthetics, however it forms explosive mixtures with air and is very flammable. It also causes vomiting and nausea. Halothane is widely used as it is not flammable and one may recover fast from it. It doesn’t irritate the respiratory tract. However, it takes time to become unconscious. It is potentially harmful to the ozone layer as it produces chlorine and bromine free radicals. B.9.4. Calculate the partial pressures of component gases in an anaesthetic mixture The partial pressure ratios of the total pressure equal the molar ratios of different gas molecules. It is important to have enough oxygen in the anaesthetic mixture so that the patient can live. At least 20% oxygen is needed B.10.1 Describe the effects of lysergic acid diethylamide (LSD), mescaline, psilocybin and tetrahydrocannabinol. Psychadelic drugs like these alter the mind and produces a change in thought, perception or mood and induce vivid fantasies. Colors seem more brilliant for the user. There are the effects of the mentioned mind altering drugs: LSD: This is a powerful hallucinogen that strongly magnifies perception and may destroy the sense of judgment. No physical addiction, and not very strong psychological dependence. Mescaline: Color hallucinations which last 12 hours. Psilocybin: Similar to LSD, especially at high doses, but at low doses produces relaxation. Shortlasting; 4 hours THC: Milder drug similar to alcohol. At larger doses, changes in perception occurs – sees bright colors and gets sharper hearing. May get extreme anxiety, depression, uneasiness, panic attacks etc. There is no tolerance, but could lead to psychological dependence. B.10.2 Discuss the structural similarities and differences between LSD, mescaline and psilocybin. LSD and psilocybin both have the Indole ring (Heterocyclic amine compound where the nitrogen atom is part of a ring). However, mescaline includes the benzene ring but not the indole ring; it does have a primary amine. Serotonin also has the indole ring. B.10.3 Discuss the arguments for and against the legalization of cannabis. Cannabis offers relief from symptoms from AIDS, cancer and glaucoma. Marijuana may increase the appetite, and relieves nausea. Cannabis helps terminally ill patients to relieve tension and anxiety. Marijuana relieves pressure inside the eyeball for glaucoma patients. However there are many bad sides to it too. Smoking marijuana may lead to lung problems and may suppress the immune system. It might lead to decreased fertility for men and cause brain damage and birth defects. Users may also start using harder drugs too. Users of prohibited drugs need to obtain it from criminal sources and may therefore be forced into crime to support their habit. It damages the society a lot.

100 Basic English Key Words for ESL Students

100 Basic English Key Words for ESL Students This list provides a starting point for a basic understanding and fluency in the English language. The list of 850 words that was developed by Charles K. Ogden, and released in 1930 with the book: Basic English: A General Introduction with Rules and Grammar. For more information about this list, you can visit Odgens Basic English page. This list is an excellent starting point for building up a vocabulary which allows you to converse fluently in English. While this list is helpful for a strong beginning, more advanced vocabulary building will help you quickly improve your English. ​These vocabulary books will further help you build your vocabulary, especially at advanced levels. Teachers can use this list as a starting point for developing an essential vocabulary to their lessons. Teachers can also use this list along with other ideas on how to teach vocabulary on this site. Basic Verbs, Prepositions, Articles, Pronouns, etc. 1. come2. get3. give4. go5. keep6. let7. make8. put9. seem10. take 11. be12. do13. have14. say15. see16. send17. may18. will19. about20. across 21. after22. against23. among24. at25. before26. between27. by28. down29. from30. in 31. off32. on33. over34. through35. to36. under37. up38. with39. as40. for 41. of42. till43. than44. a45. the46. all47. any48. every49. no50. other 51. some52. such53. that54. this55. i56. he57. you58. who59. and60. because 61. but62. or63. if64. though65. while66. how67. when68. where69. why70. again 71. ever72. far73. forward74. here75. near76. now77. out78. still79. then80. there 81. together82. well83. almost84. enough85. even86. little87. much88. not89. only90. quite 91. so92. very93. tomorrow94. yesterday95. north96. south97. east98. west99. please100. yes